VapoFil Official Website › Side Effects
Side EffectsVapoFil Side Effects And Interactions, Row By Row
Little is reported at these amounts, and the amounts are much of the reason: five rows sit at 20 mg and the trials behind those plants ran far higher. Two rows have no safety record at all because they have no trials. The one combination worth raising with a prescriber is a nitrate.
This is one of the pages whose subject is the caution, so it says so as often as it needs to. The label's own wording is quoted in full at the foot.
What is reported for each row on the VapoFil panel
Saw Palmetto Berry Extract
20 mg on this panelWell characterisedThe CAMUS safety report followed men taking up to 960 mg a day, forty-eight times what is here, and found the adverse-event profile no different from placebo. Mild digestive upset is the usual note at any dose. The pre-specified PSA analysis inside the same trial found no effect on serum prostate specific antigen, which corrects a widely repeated claim that saw palmetto masks the test.
Wild Yam Root Extract
20 mg on this panelNothing of noteThe controlled trial ran three months and reported no adverse effects and no hormonal change. Wild yam is eaten as food in several cuisines. At 20 mg of an extract there is nothing here to report.
Sarsaparilla Root Extract
20 mg on this panelNo trial recordThere is no clinical trial of sarsaparilla to draw a safety record from. Its long traditional use is reassuring in the way traditional use always is, which is to say it is not a substitute for measurement. The pharmacology review describes laboratory work rather than human safety data.
Nettle Leaf Extract
20 mg on this panelGenerally well toleratedNettle is a food plant and a long-standing herbal tea. The twelve-month root trial at 459 mg a day reported tolerability comparable to placebo, and the leaf trial in type 2 diabetes reported no safety signal either. Mild digestive effects are the usual note.
Boron Amino Acid Chelate 5%
20 mg on this panel, about 1 mg of boronDietaryAt roughly 1 mg of elemental boron this row is within what a mixed diet supplies. The review literature on boron in humans discusses intakes well above this. No Tolerable Upper Intake Level is printed anywhere on this website, because that figure could not be read from a primary source in the session that wrote these pages and an unverified number is worse than none.
Tongkat Ali, 100:1 extract
10 mg on this panelTrial-level tolerability; a sourcing questionThe clinical trials, at 100 to 400 mg a day of a standardised extract, report tolerability comparable to placebo — Ismail 2012 and Chinnappan 2021 both do. The separate question is raw material: a Malaysian survey of tongkat ali preparations found mercury above the local limit in a share of products tested. That is an argument for a documented supply chain, which is what the lot reference on this bottle is for.
Horny Goat Weed, 10:1 extract
8 mg on this panelNo human safety recordThere is no randomised trial of Epimedium or icariin in men, so there is no adverse-event table to quote. What can be said is mechanistic: icariin inhibits PDE5, the same enzyme prescription erectile medicines inhibit, and that drug class is contraindicated with nitrates because the combination can drop blood pressure sharply. Eight milligrams of a 10:1 extract is a small amount and no such interaction has been documented. Anyone on a nitrate should still mention it to the prescriber.
The interaction questions worth raising about VapoFil
Nitrates and heart medication
The one on this list that matters most. Ask the prescriber rather than this page, because the answer depends on what you take and why.
Blood thinners
Saw palmetto attracts a theoretical bleeding caution in herbal references. At 20 mg it is theoretical squared, and the CAMUS safety data at 960 mg did not surface it. Worth mentioning at a pre-operative appointment anyway.
Hormone-sensitive conditions
Several of these plants are described as hormonal in marketing copy. The evidence for any hormonal effect at these amounts is absent, but anyone treated for a hormone-sensitive condition should show the label to their doctor rather than reasoning from this page.
Other supplements in the same category
Stacking two men's vitality products doubles the ingredient overlap and the adulteration risk. A 2025 market survey found undeclared sildenafil and tadalafil in products sold as natural sexual enhancers, which is the category's real safety problem.
The VapoFil label caution, quoted in full
Do not exceed recommended dose. Pregnant or nursing mothers, children under the age of 18 and individuals with a known medical condition should consult a physician before using this or any dietary supplement.VapoFil label artwork, caution
Three things in that sentence are worth reading slowly. Do not exceed the recommended dose rules out doubling up after a missed day. Individuals with a known medical condition is broader than it looks and includes anything currently being treated. And consult a physician before using this or any dietary supplement is the label's own instruction rather than this desk's editorial addition.
The storage line matters more than it sounds for a gelatin capsule: keep away from heat, light and humidity to preserve freshness. keep out of the reach of children. do not use if the safety seal is damaged or missing. store in a cool, dry place. A bathroom cabinet is the worst place in most houses for all three reasons.
When to stop taking VapoFil and speak to somebody
- Any rash, swelling or difficulty breathing after a dose. That is an allergy question and it is urgent.
- Digestive upset that does not settle within a week of starting.
- Chest pain, dizziness or faintness, particularly if you take anything for blood pressure or angina.
- Symptoms that got suddenly worse rather than gradually better. Erectile difficulty can precede cardiovascular disease and a sudden change deserves an appointment.
- Anything you would report if it had started after a prescription rather than after a supplement. The bar should be the same.
None of the above is common at these amounts, and this page would be dishonest if it implied otherwise. A seven-ingredient botanical capsule at 98 mg of actives is not a pharmacologically dramatic product, and the section above says so ingredient by ingredient.
Who publishes this VapoFil website?
Fourteen sources, one or more behind each row and each interaction above.
- Avins AL, Lee JY, Meyers CM, Barry MJ. Safety and toxicity of saw palmetto in the CAMUS trial. J Urol. 2013;189(4):1415-20. PMID 23063633. https://pubmed.ncbi.nlm.nih.gov/23063633/
- Andriole GL, McCullum-Hill C, Sandhu GS, et al. The effect of increasing doses of saw palmetto fruit extract on serum prostate specific antigen: analysis of the CAMUS randomized trial. J Urol. 2013;189(2):486-92. PMID 23253958. https://pubmed.ncbi.nlm.nih.gov/23253958/
- Komesaroff PA, Black CV, Cable V, Sudhir K. Effects of wild yam extract on menopausal symptoms, lipids and sex hormones in healthy menopausal women. Climacteric. 2001;4(2):144-50. PMID 11428178. https://pubmed.ncbi.nlm.nih.gov/11428178/
- Hua S, Zhang Y, Liu J, et al. Ethnomedicine, Phytochemistry and Pharmacology of Smilax glabra: An Important Traditional Chinese Medicine. Am J Chin Med. 2018;46(2):261-297. PMID 29433390. https://pubmed.ncbi.nlm.nih.gov/29433390/
- Schneider T, Rübben H. Stinging nettle root extract (Bazoton-uno) in long term treatment of benign prostatic syndrome (BPS). Results of a randomized, double-blind, placebo controlled multicenter study after 12 months. Urologe A. 2004;43(3):302-6. PMID 15045190. https://pubmed.ncbi.nlm.nih.gov/15045190/
- Kianbakht S, Khalighi-Sigaroodi F, Dabaghian FH. Improved glycemic control in patients with advanced type 2 diabetes mellitus taking Urtica dioica leaf extract: a randomized double-blind placebo-controlled clinical trial. Clin Lab. 2013;59(9-10):1071-6. PMID 24273930. https://pubmed.ncbi.nlm.nih.gov/24273930/
- Nielsen FH. Update on human health effects of boron. J Trace Elem Med Biol. 2014;28(4):383-7. PMID 25063690. https://pubmed.ncbi.nlm.nih.gov/25063690/
- Ismail SB, Wan Mohammad WM, George A, et al. Randomized Clinical Trial on the Use of PHYSTA Freeze-Dried Water Extract of Eurycoma longifolia for the Improvement of Quality of Life and Sexual Well-Being in Men. Evid Based Complement Alternat Med. 2012;2012:429268. PMID 23243445. https://pubmed.ncbi.nlm.nih.gov/23243445/
- Chinnappan SM, George A, Pandey P, et al. Effect of Eurycoma longifolia standardised aqueous root extract-Physta on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicentre study. Food Nutr Res. 2021;65:5647. PMID 34262417. https://pubmed.ncbi.nlm.nih.gov/34262417/
- Ang HH, Lee EL, Cheang HS. Determination of mercury by cold vapor atomic absorption spectrophotometer in Tongkat Ali preparations obtained in Malaysia. Int J Toxicol. 2004;23(1):65-71. PMID 15162849. https://pubmed.ncbi.nlm.nih.gov/15162849/
- Dell'Agli M, Galli GV, Dal Cero E, et al. Potent inhibition of human phosphodiesterase-5 by icariin derivatives. J Nat Prod. 2008;71(9):1513-7. PMID 18778098. https://pubmed.ncbi.nlm.nih.gov/18778098/
- Omeragić E, Jesenković-Habul L, Imamović B, et al. Detection and quantification of Sildenafil and Tadalafil in dietary supplements marketed as natural sexual enhancers in Bosnia and Herzegovina. Cent Eur J Public Health. 2025;33(3):181-186. PMID 41165181. https://pubmed.ncbi.nlm.nih.gov/41165181/
- Durukan E, Jensen CFS, Grundtvig Skaarup K, Fode M. Erectile dysfunction and cardiovascular health. Nat Rev Urol. 2026. PMID 42649386. https://pubmed.ncbi.nlm.nih.gov/42649386/
- Dietary Supplements: What You Need to Know. Office of Dietary Supplements, National Institutes of Health. https://ods.od.nih.gov/factsheets/WYNTK-Consumer/
Order VapoFil on the official website
Two capsules a day is the whole amount, and the label's caution is quoted in full on this page rather than summarised.
One bottle $89 · three bottles $177 · six bottles $294 · 60-day money-back guarantee
Order VapoFil On The Official WebsiteTwo capsules a day · 60 per bottle · lot VAP-26/VA-2757
